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Tomographic and histometric analysis of autogenous bone block and synthetic hydroxyapatite block grafts without rigid fixation on rabbit calvaria

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¹è¼ö¿ë ( Bae Soo-Yong ) - Yonsei University College of Dentistry Department of Periodontology
¹ÚÁ¤Ã¶ ( Park Jung-Chul ) - Dankook University College of Dentistry Department of Periodontology
½ÅÇö½Â ( Shin Hyun-Seung ) - Dankook University College of Dentistry Department of Periodontology
ÀÌ¿ë±Ù ( Lee Yong-Keun ) - Chosun University School of Dentistry Research Center for Oral Disease Regulation of the Aged
ÃÖ¼ºÈ£ ( Choi Seong-Ho ) - Yonsei University College of Dentistry Department of Periodontology
Á¤ÀÇ¿ø ( Jung Ui-Won ) - Yonsei University College of Dentistry Department of Periodontology

Abstract


Purpose: The preferred material for bone augmentation beyond the envelope of skeletal bone is the bone block graft, due to its dimensional stability. We evaluated the necessity of rigid fixation for the bone block graft, and compared the bone regeneration and volume maintenance associated with grafting using a synthetic hydroxyapatite block (HAB) and an autogenous bone block (ABB) without rigid fixation on rabbit calvaria over two different periods.

Methods: Cylinder-shaped synthetic HAB and ABB were positioned without fixation on the rabbit calvarium (n=16). The animals were sacrificed at 4 or 8 weeks postoperatively, and the grafted materials were analyzed at each healing period using microcomputed tomography and histologic evaluation.

Results: Integration of the graft and the recipient bed was observed in all specimens, although minor dislocation of the graft materials from the original position was evident in some specimens (six ABB and ten HAB samples). A tendency toward progressive bone resorption was observed in the grafted ABB but not in the grafted HAB, which maintained an intact appearance. In the HAB group, the area of new bone increased between 4 and 8 weeks postoperatively, but the difference was not statistically significant.

Conclusions: The nonfixed HAB was successfully integrated into the recipient bed after both healing periods in the rabbit calvaria. In spite of limited bone formation activity in comparison to ABB, HAB may be a favorable substitute osteoconductive bone material.

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Animal experiments ; Bone regeneration; Hydroxyapatites

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